Inhibitors for soluble epoxide hydrolase (SEH) and fatty acid amide hydrolase (FAAH)

A compound of Formula J:

• or a pharmaceutically acceptable salt or isomer thereof, wherein
• each R1 is independently selected from the group consisting of hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, hydroxy, C1-6 hydroxyalkyl, halogen, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, —CN, —C(O)R1a, —C(O)OR1a, —OC(O)R1a, —C(O)N(R1a)(R1b), —N(R1b)C(O)R1a, —C(O)N(R1a)CH2C(O)OR1b, —N(R1a)(R1b), —S(O)2R1a, —S(O)2N(R1a)(R1b), —N(R1b)S(O)2R1a, C3-8 cycloalkyl, C5-10 heterocycloalkyl, C6-12 aryl and C5-12 heteroaryl;
• R1a is selected from the group consisting of hydrogen, C1-6 alkyl, C1-6 hydroxyalkyl, and C1-6 alkyl-C6-12 aryl;
• R1b is selected from the group consisting of hydrogen and C1-6 alkyl;
• L1 is selected from the group consisting of C6-10 arylene and C5-10 heteroarylene;
• L2 is absent or C1-6 alkylene;
• R2 is selected from the group consisting of C6-12 aryl and C5-12 heteroaryl, optionally substituted with 1 to 2 R2a groups;
• each R2a is independently selected from the group consisting of hydrogen, C6-12 aryl, —O—C6-12 aryl, C5-12 heteroaryl and —O—C5-12 heteroaryl, wherein the C6-12 aryl and C5-12 heteroaryl groups are optionally substituted with 1 to 2 R2b groups;
• each R2b is independently selected from the group consisting of halogen, C1-6 haloalkyl, C1-6 alkoxy and C1-6 haloalkoxy;
• subscript m is 1;
• and
• subscript n is an integer from 1 to 4;
• provided that when R2 is quinolin-3-yl, L2 is methylene, subscripts m and n are both 1, and L1 is phenylene, then R1 is selected from the group consisting of C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, hydroxy, C1-6 hydroxyalkyl, halogen, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, —CN, —C(O)R1a, —C(O)OR1a, —OC(O)R1a, —C(O)N(R1a)(R1b), —N(R1b)C(O)R1a, —C(O)N(R1a)CH2C(O)OR1b, —N(R1a)(R1b), —S(O)2R1a, —S(O)2N(R1a)(R1b), —N(R1b)S(O)2R1a, C3-8cycloalkyl, C5-10 heterocycloalkyl, C6-12 aryl and C5-12 heteroaryl.