Sterility retaining medical connector assembly and method

A medical connector assembly, comprising:

• a multi-use connector having a flow control element;
• a plurality of single-use connectors releasably connected to each other by a connecting arrangement in series to form a fluid path therethrough;
• a sheath disposed over an exterior of the medical connector assembly to extend from the multi-use connector and continuing along the single-use connectors connected in series, and
• wherein the multi-use connector is releasably connected to a first of the single-use connectors connected in series, and
• wherein the flow control element is configured to prevent fluid flow through the multi-use connector until a sufficient fluid pressure difference across the flow control element is reached;
• wherein the sheath comprises a first sheath element having a frangible connection to a second sheath element;
• wherein, when a second of the single-use connectors connected in series is disconnected from the first of the single-use connectors connected in series, the first sheath element remains disposed about the first of the single-use connectors connected in series and a portion of the multi-use connector and the second sheath element remains disposed about the disconnected second of the single-use connectors connected in series.