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US 10,854,318 B2Granted
Ancestry finder
Assignee23andMe, Inc.
InventorsJohn Michael Macpherson, Brian Thomas Naughton, Joanna Louise Mountain
Life of this patent
Estimating the term…
Abstract
Inferring a characteristic of an individual is disclosed. An indication that a first user and a second user have at least one shared chromosomal segment is received. Information about the second user is obtained. A characteristic of the first user is inferred based at least in part on the information about the second user.
Claims20
A method of determining and presenting an ancestral origin of at least one chromosomal segment of a first user, implemented on a computerized ancestry finder system comprising one or more processors and one or more memories, the method comprising:
- (a) receiving deoxyribonucleic acid (DNA) information of the first user and a plurality of other users, wherein the DNA information comprises hundreds of thousands of genetic markers, and wherein each user of the plurality of other users has at least two grandparents who have a same birth country or a same ethnicity;
- (b) processing in parallel, by one or more processors of the computerized ancestry finder system, the hundreds of thousands of genetic markers of the first user and the plurality of other users to determine one or more identical-by-descent (IBD) segments between the first user and the plurality of other users, wherein the processing in parallel comprises processing data of two or more users or two or more genetic markers in parallel;
- (c) identifying, by one or more processors of the computerized ancestry finder system and using the IBD segments determined in (b), one or more matching users from among the plurality of other users, wherein each matching user and the first user have at least one shared chromosomal segment that comprises a shared IBD segment of at least a minimum length;
- (d) obtaining from a database, by one or more processors of the computerized ancestry finder system, ancestry information for at least one matching user of (c), wherein the ancestry information comprises a birth country or an ethnicity of at least two grandparents of the matching user who have a same birth country or a same ethnicity;
- (e) determining, by one or more processors of the computerized ancestry finder system, the ancestral origin of at least one chromosomal segment of the first user, wherein the at least one chromosomal segment of the first user is shared with the at least one matching user of (d), and wherein the ancestral origin of the at least one chromosomal segment of the first user is determined based on the ancestry information for the at least one matching user of (d);
- and
- (f) displaying in a graphical user interface one or more views of the ancestral origin of the at least one chromosomal segment of the first user.
4 more elements
A system for determining and presenting an ancestral origin of at least one chromosomal segment of a first user, the system comprising one or more memories and one or more processors configured to:
- (a) receive deoxyribonucleic acid (DNA) information of the first user and a plurality of other users, wherein the DNA information comprises hundreds of thousands of genetic markers, and wherein each user of the plurality of other users has at least two grandparents who have a same birth country or a same ethnicity;
- (b) process in parallel the hundreds of thousands of genetic markers of the first user and the plurality of other users to determine one or more identical-by-descent (IBD) segments between the first user and the plurality of other users, wherein the processing in parallel comprises processing data of two or more users or two or more genetic markers in parallel;
- (c) identify, using the IBD segments determined in (b), one or more matching users from among the plurality of other users, wherein each matching user and the first user have at least one shared chromosomal segment that comprises a shared IBD segment of at least a minimum length;
- (d) obtain from a database ancestry information for at least one matching user of (c), wherein the ancestry information comprises a birth country or an ethnicity of at least two grandparents of the matching user who have a same birth country or a same ethnicity,
- wherein the ancestry information for the at least one matching user comprises information reported by the at least one matching user;
- (e) determine the ancestral origin of at least one chromosomal segment of the first user, wherein the at least one chromosomal segment of the first user is shared with the at least one matching user of (d), and wherein the ancestral origin of the at least one chromosomal segment of the first user is determined based on the ancestry information for the at least one matching user of (d);
- and
- (f) display in a graphical user interface one or more views of the ancestral origin of the at least one chromosomal segment of the first user.
5 more elements
A computer program product, the computer program product being embodied in a tangible non-transitory computer readable storage medium and comprising computer instructions that, when executed by a computer system, cause the computer system to determine and present an ancestral origin of at least one chromosomal segment of a first user, the computer instructions comprising:
- (a) receiving deoxyribonucleic acid (DNA) information of the first user and a plurality of other users, wherein the DNA information comprises hundreds of thousands of genetic markers, and wherein each user of the plurality of other users has at least two grandparents who have a same birth country or a same ethnicity;
- (b) processing in parallel the hundreds of thousands of genetic markers of the first user and the plurality of other users to determine one or more identical-by-descent (IBD) segments between the first user and the plurality of other users, wherein the processing in parallel comprises processing data of two or more users or two or more genetic markers in parallel;
- (c) identifying, using the IBD segments determined in (b), one or more matching users from among the plurality of other users, wherein each matching user and the first user have at least one shared chromosomal segment that comprises a shared IBD segment of at least a minimum length;
- (d) obtaining from a database ancestry information for at least one matching user of (c), wherein the ancestry information comprises a birth country or an ethnicity of at least two grandparents of the matching user who have a same birth country or a same ethnicity;
- (e) determining the ancestral origin of at least one chromosomal segment of the first user, wherein the at least one chromosomal segment of the first user is shared with the at least one matching user of (d), and wherein the ancestral origin of the at least one chromosomal segment of the first user is determined based on the ancestry information for the at least one matching user of (d);
- and
- (f) displaying in a graphical user interface one or more views of the ancestral origin of the at least one chromosomal segment of the first user.
4 more elements
Dependencies are inferred from the claim text.