Antibodies to risperidone and use thereof
AssigneeJanssen Pharmaceutica NV
InventorsEric Hryhorenko, Banumathi Sankaran, Thomas R. DeCory, Theresa Tubbs, Linda Colt, Maarten Vliegen, Pieter Rik Haspeslagh
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Abstract
Disclosed is an antibody or a binding fragment thereof that binds to risperidone, which can be used to detect risperidone in a sample such as in a competitive immunoassay method. The antibody or fragment thereof can be used in a lateral flow assay device for point-of-care detection of risperidone, including multiplex detection of aripiprazole, quetiapine, olanzapine, and risperidone in a single lateral flow assay device.
Claims20
An isolated antibody or a binding fragment thereof, which binds to risperidone, the isolated antibody or the binding fragment thereof comprising:
- (a) a light chain complementarity determining region (CDR) 1 sequence comprising amino acid residues 44 to 54 of SEQ ID NO:3, a light chain CDR2 sequence comprising amino acid residues 70 to 76 of SEQ ID NO:3, a light chain CDR3 sequence comprising amino acid residues 109 to 117 of SEQ ID NO:3, a heavy chain CDR1 sequence comprising amino acid residues 50 to 54 of SEQ ID NO:4, a heavy chain CDR2 sequence comprising amino acid residues 69 to 85 of SEQ ID NO:4, and a heavy chain CDR3 sequence comprising amino acid residues 118 to 128 of SEQ ID NO:4;
- or
- (b) a light chain CDR1 sequence comprising amino acid residues 44 to 54 of SEQ ID NO:7, a light chain CDR2 sequence comprising amino acid residues 70 to 76 of SEQ ID NO:7, a light chain CDR3 sequence comprising amino acid residues 109 to 117 of SEQ ID NO:7, a heavy chain CDR1 sequence comprising amino acid residues 50 to 54 of SEQ ID NO:8, a heavy chain CDR2 sequence comprising amino acid residues 69 to 85 of SEQ ID NO:8, and a heavy chain CDR3 sequence comprising amino acid residues 118 to 128 of SEQ ID NO:8.
Dependencies are inferred from the claim text.