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US 10,852,312 B2Granted
Determination method of blood sample, blood sample analyzer, and computer program
AssigneeSysmex Corporation
InventorOsamu Kumano
Life of this patent
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Abstract
A determination method of a blood sample may include: measuring, with a first coagulation time measurement reagent and a second coagulation time measurement reagent which contain phospholipids at different concentrations, coagulation times of a blood sample of a subject, coagulation times of a normal blood sample, and coagulation times of a mixed sample including the blood sample of the subject and the normal blood sample; acquiring a first index value and a second index value based on the coagulation times; and determining whether the blood sample of the subject is a blood sample containing a direct anticoagulant based on the first index value and the second index value.
Claims18
A determination method for determining whether a blood sample of a subject contains a direct anticoagulant, the method comprising:
- acquiring:
- a first coagulation time comprising a coagulation time of the blood sample of the subject;
- a second coagulation time comprising a coagulation time of a normal blood sample having normal blood coagulation;
- and
- a third coagulation time comprising a coagulation time of a mixed sample comprising the blood sample of the subject and the normal blood sample;
- acquiring:
- a fourth coagulation time comprising a coagulation time of the blood sample of the subject;
- a fifth coagulation time comprising a coagulation time of the normal blood sample;
- and
- a sixth coagulation time comprising a coagulation time of the mixed sample;
- acquiring:
- a first index value from the first coagulation time, the second coagulation time, and the third coagulation time;
- and
- a second index value from the fourth coagulation time, the fifth coagulation time, and the sixth coagulation time;
- and
- determining whether the blood sample of the subject is a blood sample containing the direct anticoagulant by comparing the first index value with a first threshold and by comparing the second index value with a second threshold, wherein
- the first coagulation time, the second coagulation time, and the third coagulation time are coagulation times measured by using a first coagulation time measurement reagent,
- the fourth coagulation time, the fifth coagulation time, and the sixth coagulation time are coagulation times measured by using a second coagulation time measurement reagent,
- the first coagulation time measurement reagent contains a phospholipid and the second coagulation time measurement reagent contains a phospholipid at a concentration higher than a concentration of the phospholipid in the first coagulation time measurement reagent,
- the first index value is indicative of, when compared with the first threshold, whether or not the blood sample of the subject is a blood sample containing the direct anticoagulant or a lupus anticoagulant, and
- the second index value is indicative of, when compared with the second threshold, whether or not the blood sample of the subject is a blood sample containing the direct anticoagulant.
18 more elements
A blood sample analyzer comprising:
- a measurement part configured to:
- prepare a first measurement specimen from a blood sample of a subject and from a first coagulation time measurement reagent, a second measurement specimen from a normal blood sample having normal blood coagulation and from the first coagulation time measurement reagent, a third measurement specimen from a mixed sample obtained by mixing the blood sample of the subject with the normal blood sample and from the first coagulation time measurement reagent, a fourth measurement specimen from the blood sample of the subject and from a second coagulation time measurement reagent, a fifth measurement specimen from the normal blood sample and from the second coagulation time measurement reagent, and a sixth measurement specimen from the mixed sample and from the second coagulation time measurement reagent;
- and
- acquire measurement data from the first, second, third, fourth fifth, and sixth measurement specimens;
- and
- an analysis part comprising a processor, wherein the processor is programmed to:
- acquire a first, second, third, fourth fifth, and sixth coagulation time from the measurement data;
- acquire a first index value from the first coagulation time, the second coagulation time, and the third coagulation time;
- acquire a second index value from the fourth coagulation time, the fifth coagulation time, and the sixth coagulation time;
- and
- determine whether the blood sample of the subject is a blood sample containing a direct anticoagulant by comparing the first index value with a first threshold and by comparing the second index value with a second threshold, wherein
- the first coagulation time measurement reagent contains a phospholipid and the second coagulation time measurement reagent contains a phospholipid at a concentration higher than a concentration of the phospholipid in the first coagulation time measurement reagent,
- the first index value is indicative of, when compared with the first threshold, whether or not the blood sample of the subject is a blood sample containing either the direct anticoagulant, or a lupus anticoagulant, and
- the second index value is indicative of, when compared with the second threshold, whether or not the blood sample of the subject is a blood sample containing the direct anticoagulant.
11 more elements
Dependencies are inferred from the claim text.