Back to results
US 10,852,307 B2Granted
Methods of detecting and preventing atopic allergic diseases
AssigneesNational Jewish Health, Samsung Life Public Welfare Foundation
InventorsDonald Y. M. Leung, Byung Eui Kim, Jihyun Kim, Kangmo Ahn
Life of this patent
Estimating the term…
Abstract
The present invention is related to novel methods for identifying a population of subjects that are at risk for developing of atopic allergic diseases, and to the prevention of these allergic diseases.
Claims12
A method to identify and treat a subject at risk of developing atopic dermatitis comprising:
- a. obtaining a non-lesional skin sample from an asymptomatic infant subject, by a skin tape stripping method;
- b. determining an expression level of thymic stromal lymphopoietin (TSLP) in the skin sample;
- c. comparing the expression level of TSLP in the skin sample to a control sample wherein a statically significant expression level of TSLP above the expression level of TSLP in the control sample identifies the infant subject as at risk of developing atopic dermatitis;
- and
- d. administering a pharmaceutical composition comprising a TSLP inhibiting agent selected from the group consisting of humanized antibodies that neutralize TSLP action and antibodies that bind to the TSLP receptor and/or a moisturizer for treating atopic dermatitis.
2 more elements
A method of diagnosing and treating atopic dermatitis in an asymptomatic infant subject, comprising:
- a. obtaining a non-lesional skin sample from an asymptomatic infant subject, by a skin tape stripping method;
- b. determining an expression level of thymic stromal lymphopoietin (TSLP) in the skin sample;
- c. comparing the expression level of TSLP in the skin sample to a control sample wherein a statically significant expression level of TSLP above the expression level of TSLP in the control sample identifies the infant subject as at risk of developing atopic dermatitis;
- and
- d. administering an effective amount of a topical or systemic therapeutic for treating atopic dermatitis to the subject identified as at risk of developing atopic dermatitis prior to development of atopic dermatitis symptoms.
2 more elements
Dependencies are inferred from the claim text.