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US 10,852,297 B2Granted
Screening assay for choice of prebiotic to prevent/treat gastrointestinal and systemic diseases
AssigneesRush University Medical Center, Purdue Research Foundation
InventorsAli Keshavarzian, Sander de Kivit, Bruce Hamaker
Life of this patent
Estimating the term…
Abstract
An assay and a method for identifying a prebiotic to treat a subject in need thereof to promote intestinal barrier integrity or to blunt an inflammatory response are provided.
Claims9
A composition for use in an assay for identifying a prebiotic to treat a subject in need thereof to promote intestinal barrier integrity or to blunt an inflammatory response, the composition comprising:
- a) an epithelial cell layer;
- b) a blood sample from a subject for co-culture with the epithelial cell layer;
- c) a fermentation product from the subject;
- and
- d) a prebiotic.
2 more elements
The composition according to darn 1, wherein the fermentation product is added to an apical side of the epithelial cell layer.
Dependencies are inferred from the claim text.