Assay for high-throughput identification of therapeutic compounds

A solid supported branched linker assay system, comprising:

• a.) an alpha compound and a beta compound, wherein the alpha compound and the beta compound are each reversibly tethered to a solid support;
• b.) a branched linker that is coupled to the solid support and tethers the alpha and beta compounds to the solid support;
• c.) the branched linker further comprising two cleavable linkers that are chemically distinct from one another, wherein a first chemically distinct linker tethers the beta compound to the branched linker and a second chemically distinct linker tethers the alpha compound to the branched linker;
• d.) two means for cleaving the chemically distinct linkers, wherein a first cleavage means is configured to selectively cleave the first chemically distinct linker and a second cleavage means is configured to selectively cleave the second chemically distinct linker;
• and
• (e) a growth medium inoculated with at least one microorganism of interest.