Peptides derived from Lengsin (LGSN), complexes comprising such peptides bound to MHC molecules
AssigneeImmunocore Limited
InventorsAlex Powlesland, Maurits Kleijnen
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Abstract
The present invention relates to novel peptides derived from Lengsin (LGSN), complexes comprising such peptides bound to recombinant MHC molecules, and cells presenting said peptide in complex with MHC molecules. Also provided by the present invention are binding moieties that bind to the peptides and/or complexes of the invention. Such moieties are useful for the development of immunotherapeutic reagents for the treatment of diseases such as cancer.
Claims10
A method of effecting an in vivo immune response to cells expressing Lengsin (LGSN), in a subject with non-small cell lung cancer, comprising:
- administering to the subject a therapeutically effective amount of a soluble T cell receptor (“TCR”) fused to an anti-CD3 specific antibody fragment,
- wherein the TCR is capable of specifically binding a polypeptide complexed with HLA-A*02,
- wherein the polypeptide is 8 to 16 amino acids in length and comprises
- the amino acid sequence of SEQ ID NO:
- 1.
A method of adoptive cell therapy in a subject with non-small cell lung cancer,
- comprising:
- administering to the subject T cells transfected with a vector encoding a TCR capable of specifically binding a polypeptide complexed with HLA-A *02,
- wherein the polypeptide is 8 to 16 amino acids in length and comprises the amino acid sequence of SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.