Back to results
US 10,851,356 B2Granted
Method for modifying characteristics of a lipase
AssigneeNovozymes A/S
InventorsAnna Verena Reiser, Vikram Kjoeller Bhatia, Kim Borch, Christian I. Joergensen, Birgitte Andersen, Lone Baunsgaard
Life of this patent
Estimating the term…
Abstract
The present invention relates to a method for modifying one or more characteristics of a lipase, comprising the step of associating a peptide to the lipase, wherein the peptide has at least 50% sequence identity with the amino acid sequence of at least one major lipase contact zone of the propeptide of said lipase.
Claims10
A method for modifying the stability, activity, or wash performance of a parent lipase, comprising non-covalently associating a peptide to the parent lipase to produce a modified lipase;
- where the parent lipase has at least 90% sequence identity with amino acids 1 to 269 of SEQ ID NO:
- 2;
- where the peptide has at least 90% sequence identity with the amino acid sequence of at least one major lipase contact zone of the propeptide of the parent lipase;
- and
- where the major lipase contact zone of the propeptide corresponds to any of amino acids −57 to −50;
- −40 to −28;
- and −22 to −15 of SEQ ID NO:
- 2,
- wherein the modified lipase has increased thermostability in a detergent as compared to the parent lipase, has decreased lipid stain removal activity as compared to the parent lipase, and/or has increased lipid stain removal activity after contact with a detergent or a protease as compared to the parent lipase.
6 more elements
Dependencies are inferred from the claim text.