TRPV1 modulatory gene product that affects TRPV1-specific pain behavioral responses identified in a functional screen of an HSV-based cDNA library
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsWilliam F. Goins, Joseph C. Glorioso, III, Justus Bernard Cohen, Bonnie L. Reinhart
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Abstract
The invention provides a method for ameliorating chronic pain signaling involving transient receptor potential cation channel subfamily V member 1 (TRPV1) by expressing PP1α in neurons. The invention also provides HSV vectors for expressing PP1α within neurons and compositions comprising such vectors.
Claims13
A herpes simplex virus (HSV) vector comprising an expression cassette, wherein the expression cassette comprises a nucleic acid sequence encoding PP1α operably linked to a non-native PP1α promoter wherein the expression cassette is inserted into the ICP27 locus of the HSV vector, and wherein the non-native promoter is the transient receptor potential cation channel subfamily V member 1 (TRPV1) promoter.
Dependencies are inferred from the claim text.