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US 10,851,340 B2Granted
Unitary 3D culture device
AssigneeVivabiocell S.P.A.
InventorsEric Berry, Francesco Curcio
Life of this patent
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Abstract
A continuous device for culturing mammalian cells in a three-dimensional structure for the transplantation or implantation in vivo is described. The culturing device comprises (a) a scaffold formed by a matrix of interconnected growth surfaces spaced at regular intervals and (b) a fluid distribution means at the inlet and the exit of the growth areas. The device is particularly useful for culturing bone cells for dental implants or bone reconstruction.
Claims11
A 3D lattice-shaped scaffold for tissue growth, the scaffold comprising:
- a 3D matrix of interconnected growth surfaces all uniformly spaced at regular and repetitive intervals, the interconnected growth surfaces provided by a first set of elongated three-dimensional structures extending in a first direction, a second set of elongated three-dimensional structures extending in a second direction different from the first direction, and a third set of set of elongated three-dimensional structures extending in a third direction different from the first direction and second direction;
- and
- a plurality of interconnected open spaces defined by the interconnected growth surfaces, the plurality of interconnected open spaces all being uniformly spaced at regular and repetitive intervals thereby allowing fluid to flow through the plurality of interconnected open spaces;
- wherein the uniform spacing of the interconnected open spaces provide an optimized fluid flow distribution through the scaffold;
- and
- wherein the elongated three-dimensional structures comprise fibers.
3 more elements
Dependencies are inferred from the claim text.