Anti-OX40 antibodies and methods of using the same

An isolated nucleic acid encoding an antibody or antigen binding portion thereof that binds OX40 comprising (a) the amino acid sequence of SEQ ID NO:

• 7 or 19, or an antibody or antigen binding portion thereof comprising an amino acid sequence with 90 percent homology to the amino acid sequence of SEQ ID NO:
• 7 or 19;
• (b) the amino acid sequence of SEQ ID NO:
• 8 or 20, or an antibody or antigen binding portion thereof comprising an amino acid sequence with 90 percent homology to the amino acid sequence of SEQ ID NO:
• 8 or 20;
• (c) the amino acid sequence of SEQ ID NO:
• 9 or 21, or an antibody or antigen binding portion thereof comprising an amino acid sequence with 90 percent homology to the amino acid sequence of SEQ ID NO:
• 9 or 21;
• (d) the amino acid sequence of SEQ ID NO:
• 1 or 13, or an isolated nucleic acid encoding an antibody or antigen binding portion thereof comprising an amino acid sequence with 90 percent homology to the amino acid sequence of SEQ ID NO:
• 1 or 13;
• (e) the amino acid sequence of SEQ ID NO:
• 2 or 14, or an antibody or antigen binding portion thereof comprising an amino acid sequence with 90 percent homology to the amino acid sequence of SEQ ID NO:
• 2 or 14;
• (f) the amino acid sequence of SEQ ID NO:
• 3 or 15, or an antibody or antigen binding portion thereof comprising an amino acid sequence with 90 percent homology to the amino acid sequence of SEQ ID NO:
• 3 or 15.

An isolated nucleic acid encoding an antibody or antigen binding portion thereof that binds to an epitope on OX40 recognized by an antibody (a) having a heavy chain variable region comprising the amino acid sequences of SEQ ID NO:

• 5 or 17 and a light chain variable region comprising the amino acid sequences of SEQ ID NO:
• 11 or 23, or an antibody or antigen binding portion thereof having amino acid sequences with at least 90 percent homology thereto;
• or (b) having a light chain variable region having CDRs comprising the amino acid sequences of SEQ ID NO:
• 7 or 19, SEQ ID NO:
• 8 or 20, SEQ ID NO:
• 9 or 21, or an antibody or antigen binding portion thereof having amino acid sequences with at least 90 percent homology thereto;
• or (c) having a heavy chain variable region having CDRs comprising the amino acid sequences of SEQ ID NO:
• 1 or 13, SEQ ID NO:
• 2 or 14, SEQ ID NO:
• 3 or 15, or an antibody or antigen binding portion thereof having amino acid sequences with at least 90 percent homology thereto.