Anti-SIRPα antibodies

An antibody or antigen binding fragment thereof that binds to human SIRPαV1 having the sequence of SEQ ID NO:

• 34 with an EC50 between 4.83 nM and 0.022 nM, wherein the antibody or antigen binding fragment comprises each of:
• a. a heavy chain variable region CDR1 comprising the amino acid sequence SYWMH (SEQ ID NO:69),
• b. a heavy chain variable region CDR2 comprising the amino acid sequence AIYPVNNDTTYNQKFKG (SEQ ID NO:70), AIYPVNSDTTYNQKFKG (SEQ ID NO:
• 136) or ALYPVNSDTTYNQKFKG (SEQ ID NO:
• 137),
• c. a heavy chain variable region CDR3 comprising the amino acid sequence SFYYSLDAAWFVY (SEQ ID NO:71),
• d. a light chain variable region CDR1 comprising the amino acid sequence RASQDIGSRLN (SEQ ID NO:72),
• e. a light chain variable region CDR2 comprising the amino acid sequence ATSSLDS (SEQ ID NO:73), and
• f. a light chain variable region CDR3 comprising the amino acid sequence LQYASSPFT (SEQ ID NO:74),
• or wherein the antibody or antigen binding fragment comprises each of:
• g. a heavy chain variable region CDR1 comprising the amino acid sequence NYYIH (SEQ ID NO:1),
• h. a heavy chain variable region CDR2 comprising the amino acid sequence WIYPGNVNTKYNEKFKA (SEQ ID NO:2),
• i. a heavy chain variable region CDR3 comprising the amino acid sequence PTIIATDFDV (SEQ ID NO:3),
• j. a light chain variable region CDR1 comprising the amino acid sequence KASQGVGTAVG (SEQ ID NO:4),
• k. a light chain variable region CDR2 comprising the amino acid sequence WASTRHT (SEQ ID NO:5), and
• l. a light chain variable region CDR3 comprising the amino acid sequence QQYSTYPFT (SEQ ID NO:6).