Antibodies that bind to human anti-Müllerian hormone (AMH) and their uses
AssigneeBloom Diagnostics AG
InventorAngelica Kohlmann
Life of this patent
Estimating the term…
Abstract
The present invention relates to antibodies or fragments thereof that bind to human Anti-Müllerian hormone (AMH) comprising a heavy chain CDR1 comprising the amino acid sequence of SEQ ID NO: 1, and/or a heavy chain CDR2 comprising the amino acid sequence of SEQ ID NO: 2, and/or a heavy chain CDR3 comprising the amino acid sequence of SEQ ID NO: 3; and/or comprising a light chain CDR1 comprising the amino acid sequence of SEQ ID NO: 4, and/or a light chain CDR2 comprising the amino acid sequence of SEQ ID NO: 5 and/or a light chain CDR3 comprising the amino acid sequence of SEQ ID NO: 6. The present invention further relates to antibodys or fragments thereof that bind to human Anti-Müllerian hormone (AMH) for use in a method for treating cancer in a subject.
Claims13
A method for treating cancer in a subject comprising administering to the subject in need of thereof an antibody or fragment thereof that binds to human Anti-Müllerian hormone (AMH), wherein the cancer is selected from the group consisting of breast cancer and cancer of organs of the male and female reproductive systems, wherein the antibody or fragment thereof that binds to AMH comprises a heavy chain CDR1 comprising the amino acid sequence of SEQ ID NO:
- 1, and a heavy chain CDR2 comprising the amino acid sequence of SEQ ID NO:
- 2, and a heavy chain CDR3 comprising the amino acid sequence of SEQ ID NO:
- 3;
- and a light chain CDR1 comprising the amino acid sequence of SEQ ID NO:
- 4, and a light chain CDR2 comprising the amino acid sequence of SEQ ID NO:
- 5, and a light chain CDR3 comprising the amino acid sequence of SEQ ID NO:
- 6.
A method of inhibiting growth of tumor cells of breast cancer and/or of tumor cells of organs of the male and female reproductive systems, comprising contacting the tumor cells with an antibody or fragment thereof that binds to human Anti-Müllerian hormone (AMH), wherein the antibody or fragment thereof that binds to AMR comprises a heavy chain CDR1 comprising the amino acid sequence of SEQ ID NO:
- 1, and a heavy chain CDR2 comprising the amino acid sequence of SEQ ID NO:
- 2, and a heavy chain CDR3 comprising the amino acid sequence of SEQ ID NO:
- 3;
- and a light chain CDR1 comprising the amino acid sequence of SEQ ID NO:
- 4, and a light chain CDR2 comprising the amino acid sequence of SEQ ID NO:
- 5, and a light chain CDR3 comprising the amino acid sequence of SEQ ID NO:
- 6.
An antibody or fragment thereof that binds to human Anti-Mullerian hormone (AMH), wherein the antibody or fragment thereof comprises a heavy chain CDR1 comprising the amino acid sequence of SEQ ID NO:
- 1, a heavy chain CDR2 comprising the amino acid sequence of SEQ ID NO:
- 2, and a heavy chain CDR3 comprising the amino acid sequence of SEQ ID NO:
- 3;
- and comprises a light chain CDR1 comprising the amino acid sequence of SEQ ID NO:
- 4, a light chain CDR2 comprising the amino acid sequence of SEQ ID NO:
- 5, and a light chain CDR3 comprising the amino acid sequence of SEQ ID NO:
- 6.
Dependencies are inferred from the claim text.