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US 10,851,156 B2Granted
Methods of detecting pyroglutamate amyloid beta protein (3pE Aβ) using anti-3pE Aβ antibodies
AssigneeJanssen Pharmaceutica NV
InventorsMarc Mercken, Bianca Van Broeck, Marc Vandermeeren, Bart Hermans, Astrid Bottelbergs
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Abstract
The invention provides an antibody or antigen binding fragments thereof that binds to 3pE Aβ and methods of making and using the antibody or antigen binding fragment thereof, including use for formulations, administration and kits. The antibody and antigen binding fragments thereof and methods disclosed are useful for diagnosis, prognosis and treatment of Alzheimer's disease or other β-amyloid-related diseases.
Claims15
A method of detecting amyloid β protein having pyroglutamate at the third amino acid residue (3pE Aβ) in a subject, the method comprising
- (i) contacting a biological sample from the subject with an antibody or antigen binding fragment thereof which binds to 3pE Aβ to form an antigen-antibody immune complex,
- (ii) detecting the presence of the antigen-antibody immune complex;
- wherein the antibody or antigen binding fragment thereof comprises
- a) a heavy chain variable region CDR1 comprising the amino acid sequence of SEQ ID NO:3,
- b) a heavy chain variable region CDR2 comprising the amino acid sequence of SEQ ID NO:4,
- c) a heavy chain variable region CDR3 comprising the amino acid sequence of SEQ ID NO:5,
- d) a light chain variable region CDR1 comprising the amino acid sequence of SEQ ID NO:14,
- e) a light chain variable region CDR2 comprising the amino acid sequence of SEQ ID NO:15, and
- f) a light chain variable region CDR3 comprising the amino acid sequence of SEQ ID NO:16;
- and
- wherein the biological sample is a tissue sample.
8 more elements
Dependencies are inferred from the claim text.