Middle east respiratory syndrome coronavirus neutralizing antibodies and methods of use thereof
AssigneeDana-Farber Cancer Institute, Inc.
InventorsWayne A. Marasco, Xianchun Tang
Life of this patent
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Abstract
The present invention provides antibodies that neutralize MERS-CoV and methods of use thereof. The invented antibody is used to treat MERS-CoV infections and symptoms thereof.
Claims4
A method of delaying the onset of one or more symptoms of a MERS-CoV infection, comprising administering to a person at risk of suffering from said infection, a therapeutically effective amount of a monoclonal antibody or a scFv antibody, wherein said monoclonal antibody or scFv antibody binds to an epitope in the receptor binding domain (RBD) of the spike protein of a Middle East Respiratory Syndrome coronavirus (MERS-CoV), and neutralizes MERS-CoV, and wherein the monoclonal antibody or scFv antibody comprises a VH amino acid sequence having SEQ ID NO:
- 14, and a VL amino acid sequence having SEQ ID NO:
- 16.
A method of delaying the onset of one or more symptoms of a MERS-CoV infection, comprising administering to a person at risk of suffering from said infection, a therapeutically effective amount of a monoclonal antibody or a scFv antibody, and wherein the monoclonal antibody or scFv antibody comprises a heavy chain with three CDRs comprising the amino acid sequences GGTFSSYA (SEQ ID NO:35), IIPIFGTA (SEQ ID NO:38), and ARVGYCSSTSCHIGAFDI (SEQ ID NO:39) respectively and a light chain with three CDRs comprising the amino acid sequences QSVSSS (SEQ ID NO:55), DSS (SEQ ID NO:56), and QQYSSSPYT (SEQ ID NO:57) respectively.
A method of neutralizing Middle East Respiratory Syndrome coronavirus (MERS-CoV), comprising contacting an epitope in the receptor binding domain (RBD) of the spike protein of a Middle East Respiratory Syndrome coronavirus (MERS-CoV) with a monoclonal antibody or scFv antibody, wherein the monoclonal antibody or scFv antibody comprises a heavy chain with three CDRs comprising the amino acid sequences GGTFSSYA (SEQ ID NO:35), IIPIFGTA (SEQ ID NO:38), and ARVGYCSSTSCHIGAFDI (SEQ ID NO:39) respectively and a light chain with three CDRs comprising the amino acid sequences QSVSSS (SEQ ID NO:55), DSS (SEQ ID NO:56), and QQYSSSPYT (SEQ ID NO:57) respectively, wherein the monoclonal antibody or scFv antibody neutralizes MERS-CoV.
A method of neutralizing Middle East Respiratory Syndrome coronavirus (MERS-CoV), comprising contacting an epitope in the receptor binding domain (RBD) of the spike protein of a Middle East Respiratory Syndrome coronavirus (MERS-CoV) with a monoclonal antibody or scFv antibody, wherein the monoclonal antibody or scFv antibody comprises a VH amino acid sequence having SEQ ID NO:
- 14 and a VL amino acid sequence having SEQ ID NO:
- 16.
Dependencies are inferred from the claim text.