US 10,851,151 B2 · Epitope for switching to TH17 cell and use thereof

Abstract

The present invention relates to a novel epitope to convert T cell to type 17 helper T (TH17) cell. Specifically, the present invention relates to an epitope constituting the 41st to 50th amino acids (SEQ ID No.2) of extracellular domain (ECD) of activation-inducible tumor necrosis factor receptor (AITR), an antibody recognizing the epitope, a polynucleotide encoding the epitope, a polynucleotide encoding the antibody, an expression vector comprising the polynucleotide encoding the epitope or antibody, a transformant introduced with the vector, a composition comprising the antibody for converting T cell to TH17 cell and a method of conversion for the same, a pharmaceutical composition comprising the antibody for preventing or treating infectious disease, a method for treating infectious disease using the antibody, a composition comprising the antibody for enhancing immunity, and a method for enhancing immunity using the antibody.

Claims17

Dependent claims

A method for converting a target T cell to a type 17 helper T (TH17) cell, comprising:

(a) inducing expression of activation-inducible tumor necrosis factor receptor (AITR) in a target T cell using anti-CD-3/IL-2;
and
(b) treating the target T cell using an antibody comprising
a heavy chain variable region comprising heavy chain complementarity-determining region 1 (CDR1) represented by SEQ ID NO:
6;
heavy chain CDR2 represented by SEQ ID NO:
7;
and a heavy chain CDR 3 represented by SEQ ID NO:
8;
and
a light chain variable region comprising light chain CDR1 represented by SEQ ID NO:
10;
light chain CDR2 represented by SEQ ID NO:
11;
and light chain CDR3 represented by SEQ ID NO:
12,
thereby converting a target T cell to a type 17 helper T (TH17) cell.

14 more elements

Dependencies are inferred from the claim text.

Epitope for switching to TH17 cell and use thereof

Life of this patent

Epitope for switching to TH17 cell and use thereof

Life of this patent

Abstract

Claims17