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US 10,851,142 B2Granted
Heterodimeric vascular endothelial growth factor and use thereof
AssigneeNational Health Research Institutes
InventorsAlan Yueh-Luen Lee, Jui-Ling Tsai
Life of this patent
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Abstract
A fusion protein, comprising: (i) a first vascular endothelial growth factor (VEGF) isoform, and (ii) a second VEGF isoform, and (iii) a dimerization domain between the first isoform and the second isoform, wherein the first isoform and the second isoform are selected from VEGF121 and VEGF165.
Claims12
A fusion protein, comprising:
- (i) a first vascular endothelial growth factor (VEGF) isoform, and
- (ii) a second VEGF isoform, and
- (iii) a dimerization domain between the first isoform and the second isoform, wherein the dimerization domain contains two Fc regions, and wherein the first isoform and the second isoform are selected from VEGF121 and VEGF165.
Dependencies are inferred from the claim text.