Composition, crocins active site, and uses thereof
AssigneeJinan University
InventorsXinsheng Yao, Dan Zhang, Yang Yu, Xiuqi Bao, Yang Ni, Caixia Zang
Life of this patent
Estimating the term…
Abstract
A composition, and a crocins active site extracted from Gardenia jasminoides Ellis, mainly comprising the following ingredients: crocetin di-β-D-gentiobioside, crocetin-β-D-glucopyranosyl-β-D-gentiobioside, crocetin di-β-D-glucopyranoside, 13Z-crocetin di-β-D-gentiobioside, neocrocin B, crocetin mono-β-D-gentiobioside, 13Z-crocetin-8-O-β-D-gentiobioside, 13Z-crocetin-8′-O-β-D-gentiobioside, and crocetin mono-β-D-glucopyranoside. Pharmacological experiment results show that the crocins active site can effectively improve learning and memory injuries in mice induced by scopolamine and amyloid β protein.
Claims4
A method of improving a subject's learning and memory ability, which comprises administering to the subject who is in need thereof a composition comprising therapeutically effective amounts of crocetin mono-β-D-gentiobioside, crocetin di-β-D-gentiobioside and neocrocin B, wherein said neocrocin B has the following structural formula
A method of improving a subject's learning and memory ability, which comprises administering to the subject who is in need thereof a composition comprising a therapeutically effective amount of a crocins active site extracted from Gardenia jasminoides Ellis, wherein the crocins active site comprises crocetin mono-β-D-gentiobioside, crocetin di-β-D-gentiobioside and neocrocin B, wherein said neocrocin B has the following structural formula
Dependencies are inferred from the claim text.