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US 10,851,117 B2Granted
Methods of preparing cytotoxic benzodiazepine derivatives
AssigneeImmunoGen, Inc.
InventorsMichael Reardon, Richard A. Silva
Life of this patent
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Abstract
The invention provides novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.
Claims20
A method of preparing a compound of formula (IIA):
- comprising reacting a compound of formula (IA):
- with cyanuric chloride to form the compound of formula (IIA).
A method of preparing a compound of formula (IIB):
- comprising reacting a compound of formula (IB):
- with cyanuric chloride to form the compound of formula (IIB).
Dependencies are inferred from the claim text.