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US 10,851,112 B2Granted
Anti-HCMV virus compound
AssigneeMedshine Discovery Inc.
InventorsJian Xiong, Jingjing Wang, Wentao Wu, Haizhong Tan, Xuanjia Peng, Yang Zhang, Kevin X. Chen, Jian Li, Shuhui Chen
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Abstract
Disclosed are a class of fused cyclic compounds against the HCMV virus, and use thereof in the preparation of a drugs for treating diseases associated with the HCMV virus. In particular, disclosed is the compound shown in formula (II) and pharmaceutically acceptable salts thereof.
Claims25
A compound represented by formula (II), a pharmaceutically acceptable salt or a tautomer thereof,
- wherein,
- ring A is a 5-membered heteroaromatic ring;
- R1 is H or halogen, or selected from the group consisting of C1-6 alkyl and C1-6 heteroalkyl, each of which is optionally substituted by 1, 2 or 3 R;
- R2 is H, or C1-6 alkoxy which is optionally substituted by 1, 2 or 3 R;
- R3 is H, or selected from the group consisting of C1-6 alkyl and C1-6 heteroalkyl, each of which is optionally substituted by 1, 2 or 3 R;
- T is N or C(R);
- n is 1 or 2;
- Ar is selected from the group consisting of phenyl and 6-membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 R;
- R is H, F, Cl, Br, I, OH, CN, NH2 or C(═O)NH2, or selected from the group consisting of C1-6 alkyl and C1-6 heteroalkyl, each of which is optionally substituted by 1, 2 or 3 R′;
- R′ is F, Cl, Br, I, OH, CN, NH2, COOH, Me, Et, CF3, CHF2, CH2F, NHCH3 or N(CH3)2;
- the heteroatom or heteroatom group in the 5-membered heteroaromatic ring, 6-membered heteroaryl or C1-6 heteroalkyl is selected from the group consisting of —C(═O)NH—, —NH—, —S(═O)2NH—, —S(═O)NH, —O—, —S—, N, —C(═O)O—, —C(═O)—, —S(═O)— and —S(═O)2—;
- in any of the above cases, the number of the heteroatom or the heteroatom group is independently 1, 2 or 3.
9 more elements
A compound, a pharmaceutically acceptable salt or a tautomer thereof, which is selected from the group consisting of
- or, is selected from the group consisting of
Dependencies are inferred from the claim text.