Dipeptide piperidine derivatives

A compound of the Formula (I):

• wherein:
• R1 is selected from the group consisting of H, straight-chain or branched (C1-C6)alkyl, HC(O)—, and (C1-C6)alkyl-C(O)—;
• R2 and R3 are each independently selected from hydrogen, straight-chain or branched (C1-C6)alkyl or (C1-C6)alkyl-C(O)—,
• or R2 and R3 taken together with the boron atom and oxygen atoms to which they are bound form a 4-, 5-, 6- or 7-membered ring that is fully saturated, or partially saturated,
• or R2 and R3 taken together with the boron atom and oxygen atoms to which they are bound form a diester of the boronic acid and polyalcohols selected from:
• pinanediol, mannitol, glycerol, xylitol, sorbitol, or erythritol,
• or R2 and R3 taken together with the boron atom and oxygen atoms to which they are bound form an anhydride or mixed ester-anhydride of the boronic acid and hydroxy acids or di-carboxylic acids selected from:
• iminodiacetic acid or N-methyliminodiacetic acid or oxalic acid or tartaric acid or citric acid or malic acid or malonic acid or mandelic acid or glycolic acid or lactic acid or 3-hydroxypropionic acid;
• R4 is selected from the group consisting of H, straight-chain and branched (C1-C6)alkyl;
• R5 is selected from the group consisting of H, F, methyl, ethyl, propyl, isopropyl, —CH2NH2, —CH2NHCH3, —CH2NHCH2CH3, —CH2NHCH(CH3)2, —CH2N(CH3)2, —CH2N(CH3)CH2CH3, —CH2N(CH2CH3)2, —CH2N(CH3)CH(CH3)2, —CH2-azetidinyl, —CH2-pyrrolidinyl, and —CH2-piperidinyl;
• R6 is selected from the amino acid side chains of Gly, Ala, Val, Ser, Phe, Lys, Thr, Met, Tyr, His, Asp, Glu, Asn, Gln, Cys, Sec, Ile, Leu, Arg, Orn, Cit, Trp, 1-Me-Trp and Nva;
• and
• R7 and R8 are each independently selected from hydrogen and methyl,
• or, when R7 is H, R6 and R8 together with the nitrogen atom carrying R8 form a pyrrolidine ring (proline side chain);
• or a pharmaceutically acceptable salt thereof.