Methods and agents for treating disease
AssigneeAngion Biomedica Corp.
InventorsBijoy Panicker, Lambertus J. W. M. Oehlen
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Abstract
The present invention provides compounds having the general structural formula (I) and pharmaceutically acceptable derivatives thereof, as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of conditions or diseases involving elevated levels of aldosterone or abnormal or excessive fibrosis, such as kidney disease and hypertension.
Claims23
A method of treating or lessening the severity of renal fibrosis in a subject, comprising administering to the subject in need thereof a compound of Formula (I):
- or a salt thereof;
- wherein R1 and R2 are each independently one or more H, halogen, haloalkyl, NO2, CN, COOR5, SO2R5, CONR5R6, SO2NR5R6, NR5R6, OR5, alkyl, alkenyl, alkynyl, heteroalkyl, aryl or heteroaryl, each of which is optionally substituted with one or more R7;
- or two R2 substituents, taken together with the respective carbon atoms to which they are attached, form a 5-6 membered heterocyclic ring, wherein said ring is optionally substituted with one or more R7;
- R3 is H, alkyl, alkenyl or alkynyl, each of which is optionally substituted with one or more R7;
- R4 is H, NR5R6, SR5, or OR5;
- R5 and R6 are each independently hydrogen, alkyl, aryl, heteroaryl or haloalkyl;
- each R7 is independently H, halogen, alkyl, haloalkyl, NO2, CN, COOR8, SO2R8, CONR8R9, SO2NR8R9, NR8R9, or OR8;
- and
- R8 and R9 are each independently hydrogen, alkyl or haloalkyl.
Dependencies are inferred from the claim text.