Piperazine derivatives as TRPML modulators

A compound of formula I:

• or a salt thereof;
• or a prodrug, or a salt of a prodrug thereof;
• or a hydrate, solvate, or polymorph thereof, wherein:
• each X is independently CR6 or N;
• Y is NR7 or CR8R9;
• Ary is phenyl or heteroaryl optionally substituted with 1, 2, or 3 substituents independently selected from C1-3 alkyl, halo, OH, CN, OR, NHR, NRR′, N(R)C(═O)R′, N(R)C(═O)(O)R′, OC(═O)NRR′, C(═O)R, C(═O)NRR′, N(R)S(O)2R′, S(O)2R, and S(O)2NRR′;
• R1, R2, R3, R4, R5, R6, R7, R8, R9 each are independently H, C1-3 alkyl, halogen, oxo, OH, CN, OR, NHR, NRR′, N(R)C(═O)R′, N(R)C(═O)(O)R′, OC(═O)NRR′, C(═O)R, C(═O)NRR′, N(R)S(O)2R′, S(O)2R, or S(O)2NRR′;
• R, R′ each are independently H, or C1-3 alkyl;
• and wherein said compound is other than:
• wherein X, Y, Ary, R1, R2, R3, R4, and R5 are as defined above.