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US 10,851,083 B2Granted
Benzoimidazoles as prolyl hydroxylase inhibitors
AssigneeJanssen Pharmaceutica NV
InventorsFrances Meredith Hocutt, Barry Eastman Leonard, Jr., Hillary M. Peltier, Victor K. Phuong, Michael H. Rabinowitz, Mark D. Rosen, Kyle T. Tarantino, Hariharan Venkatesan, Lucy Xiumin Zhao
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Abstract
The present invention is directed to benzoimidazole compounds of the formula: and enantiomers, diastereomers, racemates, and pharmaceutically acceptable salts thereof. Compounds of the present invention are useful in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions modulated by prolyl hydroxylase activity.
Claims4
A compound having PHD inhibitor activity of the formula (I):
- wherein:
- n is 2-4;
- each R1 is independently selected from H, halo, —C1-4perhaloalkyl, trifluoroC1-4-alkoxy, and —SC1-4alkyl;
- R2 and R3 are both H, —CF3, or C1-3alkyl;
- each Z is C;
- or an enantiomer, a diastereomer, a racemate, or a pharmaceutically acceptable salt thereof.
3 more elements
Dependencies are inferred from the claim text.