Methods of treatment using pyrrolidinyl urea, thiourea, guanidine and cyanoguanidine compounds

A method for treating a disease or disorder selected from pain and cancer, in a mammal in need thereof, which comprises administering to said mammal a therapeutically effective amount of a compound of Formula I compound of Formula I:

• or a pharmaceutically acceptable salt thereof, wherein:
• Ring B and the NH—C(═X)—NH moiety are in the trans configuration;
• Ra, Rb, Rc and Rd are H;
• X is O;
• R1 is (1-3C alkoxy)(1-6C)alkyl;
• R2 is H;
• Ring B is Ar1;
• Ar1 is phenyl optionally substituted with one or more substituents independently selected from halogen;
• Ring C is
• R3 is Ar2;
• Ar2 is phenyl optionally substituted with one or more substituents independently selected from halogen;
• R4 is selected from (1-6C alkyl)SO2—, (1-6C alkyl)C(═O)— and from the structures:
• Rm is (1-3C)alkyl substituted with 1-3 fluoros, or (3-4C)cycloalkyl;
• Rn is (1-3C)alkyl;
• Rq is (1-3C)alkyl optionally substituted with 1-3 fluoros;
• Rx is (1-6C)alkyl, halogen, CN, hydroxy(1-6C)alkyl, trifluoro(1-6C)alkyl, (3-6C)cycloalkyl, (3-6C cycloalkyl)CH2—, (3-6C cycloalkyl)C(═O)—, (1-3C alkoxy)(1-6C)alkyl, (1-6C)alkoxy, (1-6C)alkylsulfonyl, NH2, (1-6C alkyl)amino, di(1-6C alkyl)amino, trifluoro(1-3C)alkoxy or trifluoro(1-6C)alkyl;
• n is 0, 1, 2, 3 or 4;
• m is 0, 1, 2 or 3;
• Ry is F or (1-3C)alkyl optionally substituted with 1-3 fluoros;
• p is 0, 1 or 2;
• Rz is (3-4C)cycloalkyl, or (1-3C)alkyl optionally substituted with 1-3 fluoros;
• and
• R5 is (1-6C)alkyl.