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US 10,851,071 B2Granted
M-dihydroxybenzene derivative crystal and salt, and manufacturing method thereof
AssigneeChia Tai Tianqing Pharmaceutical Group Co., Ltd.
InventorsXiaobing Yan, Wei Huang, Dan Li, Charles Z. Ding, Fei Liu, Xiquan Zhang
Life of this patent
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Abstract
Provided are a crystal and salt of an m-dihydroxybenzene derivative represented by formula (I), a manufacturing method thereof, and an application of the crystal in preparing a pharmaceutical product for treating a HSP90-mediated disease.
Claims18
A compound of formula (I) in crystalline form,
- or a salt of the compound of formula (I), wherein the salt of the compound of formula (I) is selected from:
- trifluoroacetate, methanesulfonate, ρ-toluenesulfonate, citrate, maleate, fumarate, hydrobromide, phosphate or sulfate, or a compound of formula (II),
- wherein HA is selected from trifluoroacetic acid, methanesulfonic acid, ρ-toluenesulfonic acid, citric add, maleic acid, fumaric acid, hydrochloric acid, hydrobromic acid, phosphoric acid, and sulfuric acid
- wherein HA is selected from trifluoroacetic acid, methanesulfonic acid, ρ-toluenesulfonic acid, citric acid, maleic acid, fumaric acid, hydrochloric acid, hydrobromic acid, phosphoric acid, and sulfuric acid±characterized in that the X-ray powder diffraction pattern of the compound of formula (I) in crystalline form has diffraction peaks at the following 2θ angles:
- 10.66±0.2°, 15.09±0.2°, 19.17±0.2°.
2 more elements
Dependencies are inferred from the claim text.