Processes for the resolution of benzodiazepin-2-one and benzoazepin-2-one derivatives

A process for the preparation of a compound of Formula (I-0):

• wherein X is N;
• R1 is halogen, CN or optionally substituted C1-C3 alkyl;
• and n is 0, 1, 2 or 3;
• said process comprising:
• (a) reacting a compound of Formula (I′-0),
• with a compound of Formula (III),
• wherein R is optionally substituted phenyl, in a solvent selected from acetonitrile, methanol, tetrahydrofuran, 2-methyltetrahydrofuran, ethyl acetate, 1,2-dimethoxyethane, dichloromethane, 1,4-dioxane, toluene, anisole, ethanol, acetone, N,N-dimethylformamide, N,N-dimethylacetamide, pyridine and isopropyl acetate, or a combination of two or more thereof and at a temperature of 20° C. to 45° C., to yield a compound of Formula (IV-0),
• provided that said reaction takes place in the absence of an aromatic aldehyde;
• and
• (b) treating the compound of Formula (IV-0) with a base to provide the compound of Formula (I-0).