Compositions of crystallized hydrophobic compounds and methods of making and using same
AssigneeMassachusetts Institute of Technology
InventorsShady Farah, Joshua C. Doloff, Robert S. Langer, Daniel G. Anderson
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Abstract
The present invention provides, in certain embodiments, compositions comprising a uniform population of free, single crystals of a hydrophobic compound. Methods of administering, and processes for preparing, compositions comprising a uniform population of free, single crystals of a hydrophobic compound are also provided.
Claims20
A uniform population of free, single crystals of a compound having chemical formula (I):
- or a salt thereof, wherein each free, single crystal in the population has a characteristic dimension of at least about 1 micrometer.
A method of delivering to a subject a uniform population of free single crystals of a compound having chemical formula (I):
- or a pharmaceutically acceptable salt thereof, comprising:
- administering to the subject a uniform population of free single crystals of a compound having chemical formula (I), or a pharmaceutically acceptable salt thereof, wherein each free, single crystal in the population has a characteristic dimension of at least about 1 micrometer,
- thereby delivering the uniform population of free single crystals of the compound having chemical formula (I), or a pharmaceutically acceptable salt thereof, to the subject.
A polymorph of a compound represented by chemical formula (I):
- characterized by at least five major powder x-ray diffraction peaks at 2θ angles selected from 18.42°, 19.46°, 19.88°, 21.4°, 21.64°, 22.22°, 23.82°, 29.64° and 31.08°.
Dependencies are inferred from the claim text.