1,4-substituted piperidine derivatives

A method of treating a subject who is suffering from a condition, disease, or disorder, wherein said condition, disease, or disorder is obesity, an eating disorder, cardiovascular disease, a gastrointestinal disorder, a dermatological disorder, metabolic disease, a viral disorder wherein FASN inhibition correlates inhibition of viral replication, cancer, or cancer metastasis, said method comprising administering to the subject a therapeutically

• effective amount of a compound according to Formula V(a):
• or a pharmaceutically acceptable salt thereof, wherein:
• R1b is selected from —NR7R8 and —N(OR8)R7;
• R4 is selected from —H, —(C1-C6) alkyl, —OH, —O(C1-C6) alkyl, halogen, and —CN;
• X is selected from —O— and —S—;
• R5 is selected from —H, —C1-C7 hydrocarbyl, —C3-C6 heterocyclyl;
• halogen, —(C1-C3) haloalkyl, —OR7a, —CN, —NR7aR8a, —O(CH2)nNR7aR8a, —O(CH2)nOR8a, —NR8a(CH2)nNR7aR8a, —NR8a(CH2)nOR8a, —C(═O)NR7aR8a, —C(═O)OR7a, 5-6 membered heteroaryl and substituted 5-6 membered heteroaryl;
• n is an integer selected from 1, 2, 3, and 4;
• R7 is selected from —H, —(C1-C7) hydrocarbyl, substituted —(C1-C7) hydrocarbyl, —C(═O)R8, and —(C1-C6) heteroalkyl;
• R8 is selected from —H, and —(C1-C6) alkyl, wherein R7 can optionally be structurally connected to R8 to form a 5 to 7 membered heterocyclyl ring;
• R7a is selected from —H, —(C1-C7) hydrocarbyl, substituted —(C1-C7) hydrocarbyl, —C(═O)R8, and —(C1-C6) heteroalkyl;
• R8a is selected from —H, and —(C1-C6) alkyl, wherein R7a can optionally be structurally connected to R8a to form a 5 to 7 membered heterocyclyl ring;
• Q1, Q2, Q3, Q4, Q5, Q6 and Q7 are independently selected from N and C—R12, provided that 1, 2 or 3 of Q1, Q2, Q3, Q4, Q5, Q6 and Q7 are N, and the remainder of Q1, Q2, Q3, Q4, Q5, Q6 and Q7 are C—R12;
• each R12 is independently selected from —H, halogen, —(C1-C6) alkyl, —(C3-C6) cycloalkyl, 5-6 membered heterocyclyl, —OH, —O(C1-C6) alkyl, —O(CH2)p-(5-6 membered heterocyclyl), —O(CH2)p—O(C1-C6) alkyl, —NH2, —CN, —NH(C1-C6) alkyl, —N(C1-C6 alkyl)2, —NH(CH2)p—O(C1-C6) alkyl, —NH(CH2)p—N(C1-C6 alkyl)2, —C(═O)NH2, —C(═O)NH(C1-C6) alkyl, and —C(═O)N(C1-C6 alkyl)2;
• and
• p is an integer selected independently from 1, 2, 3, and 4.