Derivatives of indole for the treatment of cancer, viral infections and lung diseases
AssigneesBiokinesis, Centre National De La Recherche Scientifique
InventorsCecile Bougeret, Catherine Guillou, Julien Rouleau, Julie Rivollier, Denis Carniato
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Abstract
The present invention relates to a new class of indole derivatives, having a particular MKlp2 inhibition profile and useful as a therapeutic agent, in particular for the treatment of cancer, viral infections and lung diseases.
Claims15
A method for reducing tumor volume or ameliorating cancer in a subject comprising administering to said subject having a cancer selected from leukemia, acute myelogenous leukemia, lymphoma, breast cancer, pancreatic cancer, lung cancer and colon cancer an effective amount of a pharmaceutical composition comprising (E)-3-(2-(5-bromo-1H-indol-3-yl)-2-cyanovinyl)-4-methoxybenzonitrile, (Z)-3-(2-(5-bromo-1H-indol-3-yl)-2-cyanovinyl)-4-methoxybenzonitrile, or pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.