Chemical compounds

A method of treating a disease selected from Alzheimer's disease, spinal cord injury, traumatic brain injury, ischemic stroke, stroke, diabetes, Parkinson disease, Huntington's disease, Creutzfeldt-Jakob Disease, and related prion diseases, progressive supranuclear palsy, amyotrophic lateral sclerosis, myocardial infarction, cardiovascular disease, inflammation, fibrosis, chronic and acute diseases of the liver, chronic and amuicute diseases of the lung, chronic and acute diseases of the kidney, chronic traumatic encephalopathy (CTE), neurodegeneration, dementia, cognitive impairment, atherosclerosis, ocular diseases, in organ transplantation and arrhythmias, in a mammal in need thereof, which comprises administering to such mammal a therapeutically effective amount of a compound represented by the following Formula:

• wherein:
• X11 and X12 are independently —CH— or —N—;
• L12 and L13 are independently:
• —NH—, —N(CH3)—, —NH—CH2—, —CH2—C(O)—NH—, —NH—C(O)—CH2—, —CH2—O—, —CH2—CH2—O—,—CH2—CH2—CH2—O—;
• —O—CH2—, —O—CH2—CH2— or —O—CH2—CH2—CH2—;
• L11 is selected from:
• a bond, —O—, —CH2—, —CH2—CH2—, and —CH2—CH2—CH2—;
• Y11 is hydrogen or is C1-2alkyl and taken together with L12 to form piperidinyl, tetrahydrofuranyl or tetrahydropyranyl;
• Y12 is hydrogen or is C1-2alkyl and taken together with L13 to form tetrahydrofuranyl or tetrahydropyranyl;
• R11 is selected from:
• hydrogen, methyl, fluoro, —OH;
• R15 and R16 are independently hydrogen, —CH3—, —OCH3—, —CF3—, fluoro or chloro;
• R12 and R14 are O;
• z12 and z14 are independently 0 or 1;
• and
• z15 and z16 are independently an integer from 0 to 2;
• or a salt thereof including a pharmaceutically acceptable salt thereof.