De novo design of potent and selective interleukin mimetics
AssigneesUniversity of Washington, The Board of Trustees of the Leland Stanford Junior University
InventorsDaniel Adriano Silva Manzano, Shawn Yu, Umut Ulge, David Baker, Kenan Christopher Garcia, Jamie Spangler, Carl Walkey
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Abstract
De novo designed polypeptides that bind to IL-2 receptor βc heterodimer (IL-2Rβc), IL-4 receptor αc heterodimer (IL-4Rαc), or IL-13 receptor α subunit (IL-13Rα) are disclosed, as are methods for using and designing the polypeptides.
Claims30
A non-naturally occurring polypeptide comprising an amino acid sequence at least 80% identical to the amino acid sequence set forth in SEQ ID NO:181 provided that a cysteine residue is at amino acid position 62, 69 or 73 of SEQ ID NO:181, wherein the polypeptide binds to IL-2 receptor βc heterodimer (IL-2Rβc).
Dependencies are inferred from the claim text.