Integrated electrowetting nano-injector and aspirator

A system configured to use an integrated electrowetting to stimulate an injection or an aspiration of a biomaterial, wherein the biomaterial is an aqueous solution comprising an organic phase and an aqueous phase, the system comprising a single probe which comprises:

• (a) a nano-pipette having an aperture with dimensions in the nanoscale region, wherein an organic phase is disposed in the nano-pipette;
• (b) an outer electrode coupled to and directly attached on an outer surface of the nano-pipette;
• (c) an inner electrode disposed in the organic phase within the nano-pipet,
• wherein a potential difference is applied between the outer electrode and the inner electrode to electrically change a wetting angle at an interface between the organic phase and the aqueous solution, said change effectively stimulating the movement of the aqueous solution,
• wherein when the potential difference exceeds a threshold voltage, the aqueous solution is extracted and drawn into the nano-pipette, and
• wherein When the potential difference is lower than the threshold voltage, the aqueous solution is injected and drawn out of the nano-pipette.