Compositions and methods of enhancing immune responses to Eimeria
AssigneesBoard of Trustees of the University of Arkansas, The Texas A&M University System, University of Guelph
InventorsWalter Bottje, Billy Hargis, Luc Berghman, Young Min Kwon, Kimberly Cole, Mandy Cox, Sherryll Layton, Saeed El-Ashram, John Barta, Guillermo Tellez
Life of this patent
Estimating the term…
Abstract
Vaccines comprising TRAP polypeptides and Salmonella enteritidis vectors comprising TRAP polypeptides are provided. The vaccines may also include a CD154 polypeptide capable of binding to CD40. Also provided are methods of enhancing an immune response against Apicomplexan parasites and methods of reducing morbidity associated with infection with Apicomplexan parasites.
Claims22
A vaccine comprising a vector comprising a first polynucleotide sequence encoding a thrombospondin-related anonymous protein (TRAP) polypeptide consisting of SEQ ID NO:
- 1, SEQ ID NO:
- 2 or SEQ ID NO:
- 3 or a fragment thereof comprising at least six consecutive amino acids of SEQ ID NO:
- 1, SEQ ID NO:
- 2 or SEQ ID NO:
- 3, wherein the polypeptide is expressed on a surface of the vector.
Dependencies are inferred from the claim text.