Compositions and methods that promote hypoxia or the hypoxia response for treatment and prevention of mitochondrial dysfunction and oxidative stress disorders
AssigneesThe General Hospital Corporation, Massachusetts Institute of Technology
InventorsVamsi K. Mootha, Isha Jain, Warren M. Zapol, Luca Zazzeron
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Abstract
Methods of promoting hypoxia or the hypoxia response for the treatment or prevention of mitochondrial dysfunction and oxidative stress disorders are described. Methods for screening for targets of mitochondrial dysfunction and oxidative stress disorders are also described.
Claims35
A method of treating or preventing mitochondrial dysfunction in a subject in need thereof, the method comprising administering to the subject by inhalation continuously for at least two hours a therapeutically effective amount of a therapeutic gas comprising between 5 to 20% O2.
A method of treating or preventing an oxidative stress disorder in a subject in need thereof, the method comprising administering to the subject by inhalation continuously for at least two hours a therapeutically effective amount of a therapeutic gas comprising between 5 to 20% O2.
Dependencies are inferred from the claim text.