Medical devices including medicaments and methods of making and using same including enhancing comfort, enhancing drug penetration, and treatment of myopia

A method of using a medical device contact lens for delivery of at least one drug to the eye of a subject in need of treatment, prevention, control, reduction of the severity, or reduction of progression of myopia, comprising:

• a) providing a subject in need of treatment, prevention, control, or reduction of the severity of myopia;
• b) operably engaging a medical device contact lens comprising one or more drugs with at least one eye of said subject;
• wherein said medical device contact lens comprises:
• a) a contact lens comprising a first surface and a second surface;
• b) said contact lens further comprising at least one coating provided on at least a portion of said first surface, said second surface, or a combination thereof as opposed to within said contact lens, wherein said at least one coating comprises at least one drug;
• 1) said at least one coating comprising at least one three dimensional structure;
• 2) said at least one three dimensional structure comprising:
• a. one or more drug reservoir layers;
• wherein said one or more drug reservoir layers comprise at least one drug;
• and
• b. one or more barrier layers;
• c) wherein said one or more barrier layers modulate the release of said one or more drugs from said contact lens;
• d) wherein said one or more drug reservoir layers, said one or more barrier layers, or a combination thereof, are oriented vertically, horizontally, or a combination thereof, relative to each other;
• further wherein said at least one drug can treat, prevent, control, reduce the severity, or reduce the progression of myopia in a subject in need thereof;
• and
• further wherein said at least one drug is released from said contact lens in a pharmaceutically effective amount to treat, prevent, control, reduce the severity, or reduce the progression of myopia in a subject when said medical device is operably engaged with the eye of said subject.