Thalidomide analogs and methods of use
AssigneesThe United States of America, as represented by the Secretary, Department of Health and Human Services, The University Court of the University of Aberdeen
InventorsNigel H. Greig, Weiming Luo, David Tweedie, Neil Vargesson, Shaunna Beedie, William Douglas Figg
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Abstract
Thalidomide analogs and methods of using the thalidomide analogs are disclosed. Some embodiments of the disclosed compounds exhibit anti-angiogenic and/or anti-inflammatory activity. Certain embodiments of the disclosed compounds are non-teratogenic.
Claims20
A method for inhibiting TNF-α activity, TNF-α synthesis, angiogenesis, inflammation, or a combination thereof, comprising contacting a cell with an effective amount of a thalidomide analog or a pharmaceutically acceptable salt thereof, the thalidomide analog selected from compound 7, compound 9, compound 44, compound 69, compound 72, compound 76, compound 77, or any combination thereof:
Dependencies are inferred from the claim text.