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US 10,836,717 B2Granted
Reagents for fluorosulfating alcohols or amines
AssigneesBioduro, LLC, Pfizer Inc.
InventorsHua Zhou, Paramita Mukherjee, Rongqiang Liu, Christopher W. Am Ende, Tianjing Deng
Life of this patent
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Abstract
Disclosed herein are compounds of formula Ar—N(SO2F)2, wherein Ar is selected from an optionally substituted aryl, an optionally substituted five-membered heteroaryl, or an optionally substituted six-membered heteroaryl. Also disclosed are methods of synthesizing the above compounds by reacting a compound of formula Ar—NH—R9 with MN(SO2F)2.
Claims10
A compound of Formula I:
- Ar—N(SO2F)2 (I)
- wherein Ar is a moiety of Formula II:
- wherein:
- each of X1, X2, X3, X4, and X5 is carbon;
- each of R1, R2, R4, and R5 is independently selected from hydrogen, halide, an optionally substituted alkyl, an optionally substituted aryl, an optionally substituted five-membered heteroaryl, or an optionally substituted six-membered heteroaryl, or a moiety of formula R6—C(═O)-NH-, wherein R6 is selected from hydrogen, an optionally substituted alkyl, an optionally substituted aryl, an optionally substituted five-membered heteroaryl, or an optionally substituted six-membered heteroaryl;
- R3 is selected from halide, an optionally substituted aryl, an optionally substituted five-membered heteroaryl, or an optionally substituted six-membered heteroaryl, or a moiety of formula R6—C(═O)—NH—, wherein R6 is selected from hydrogen, an optionally substituted alkyl, an optionally substituted aryl, an optionally substituted five-membered heteroaryl, or an optionally substituted six-membered heteroaryl.
3 more elements
Dependencies are inferred from the claim text.