Method for determining the temporal progression of a biological phenomenon and associated methods and devices

A method for determining the temporal progression of a biological phenomenon which may affect a studied subject, the method comprising:

• providing first data, the first data being data relative to biomarkers for the studied subject, the biomarkers being relative to the progression of the biological phenomenon,
• providing a numerical model (NM), the numerical model (NM) being a function in a Riemann manifold (RM), the numerical model (NM) associating to values of biomarkers a temporal progression trajectory for the biological phenomenon and data relative to the dispersion of the progression trajectory for the biological phenomenon among a plurality of subjects, the numerical model (NM) being obtained by using a stochastic approximation in an expectation-maximization technique on data relative to biomarkers taken at different time points for a plurality of subjects,
• converting the first data into at least one point on the same Riemann manifold (RM), and
• using the numerical model (NM) to determine a temporal progression for the biological phenomenon for the studied subject.