Device and system for collecting and analyzing vapor condensate, particularly exhaled breath condensate, as well as method of using the same
AssigneeEssenlix Corporation
InventorsStephen Y. Chou, Wei Ding
Life of this patent
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Abstract
The present invention is related to the field of bio/chemical sensing, assays and applications. Particularly, the present invention is related to collecting a small amount of a vapor condensate sample (e.g. the exhaled breath condensate (EBC) from a subject of a volume as small as 10 fL (femto-Liter) in a single drop), preventing or significantly reducing an evaporation of the collected vapor condensate sample, analyzing the sample, analyzing the sample by mobile-phone, and performing such collection and analysis by a person without any professionals.
Claims92
A method for analyzing an analyte in a vapor sample, comprising:
- (a) having a device comprising a first plate, a second plate, and one or more spacers, wherein
- i. the first plate and the second plate are movable relative to each other into different configurations, including an open configuration and a closed configuration;
- ii. each plate has a sample contact area for contacting a vapor sample that contains or is suspected to contain an analyte;
- and
- iii. one or both of the sample contact areas has at least one of the spacers;
- (b) depositing, in the open configuration, the vapor sample on one or both of the plates by directly condensing a vapor of the vapor sample on the plate or the plates;
- (c) bringing, after step (b), the two plates into the closed configuration;
- and
- (d) analyzing, after step (c), the vapor sample to generate a result;
- wherein in the open configuration, the two plates are either completely or partially separated apart, and the spacing between the plates is not regulated by the spacers, and in the closed configuration, at least a part of the vapor sample is between the two plates and in contact with the two plates, and has a thickness that is regulated by the spacers and the surfaces of the plates and is 30 um or less.
Dependencies are inferred from the claim text.