Solvate form of (R)-2-amino-3-phenylpropyl carbamate
AssigneesJazz Pharmaceuticals Ireland Limited, SK Biopharmaceuticals Co., Ltd.
InventorsJennifer Leigh Nelson, Fionn Hurley
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Abstract
The present invention relates to a newly identified solvate form of (i?)-2-amino-3-phenylpropyl carbamate (APC) hydrochloride, a method of preparing APC hydrochloride, and methods of using the same to treat disorders. The invention further relates to methods of producing APC hydrochloride with increased purity.
Claims27
A solvate form of (R)-2-amino-3-phenylpropyl carbamate hydrochloride characterized by a powder x-ray diffraction pattern substantially the same as that shown in FIG. 1 Form B.
A process of preparing a solvate form of (R)-2-amino-3-phenylpropyl carbamate hydrochloride, comprising slurrying (R)-2-amino-3-phenylpropyl carbamate hydrochloride in acetonitrile/water (95%/5% v/v) and collecting the solvate by vacuum filtration.
A method of preparing (R)-2-amino-3-phenylpropyl carbamate hydrochloride while minimizing contamination with 2-chloropropane, the method comprising crystallizing (R)-2-amino-3-phenylpropyl carbamate in the presence of aqueous HCl, thereby producing crystals of (R)-2-amino-3-phenylpropyl carbamate hydrochloride.
A solvate form of (R)-2-amino-3-phenylpropyl carbamate hydrochloride characterized by a powder x-ray diffraction pattern having peaks at about 7.0, 13.6, 16.2, 17.4, 17.8, 18.5, 21.0, 21.7, 22.7, 23.0, 24.0, and 27.3±0.2 °2θ.
Dependencies are inferred from the claim text.