Naphthoquinones, pro-drugs, and methods of use thereof

A compound of the formula:

• wherein:
• R1 is halo, nitro, substituted alkyl(C≤8), substituted alkoxy(C≤8), or —NRaRb, wherein:
• Ra or Rb are each independently hydrogen or —C(O)-alkoxy(C≤12), alkyl(C≤12), acyl(C≤12), alkylsulfonyl(C≤12), arylsulfonyl(C≤12), or a substituted version of any of these groups;
• or
• when n is more than 1, then both R1 are taken together and are an alkoxydiyl(C≤6) or substituted alkoxydiyl(C≤6);
• or
• —O-alkanediyl(C≤6)-Rc, wherein:
• Rc is amino, alkylamino(C≤8), dialkylamino(C≤8), heterocycloalkyl(C≤8), or a substituted version of any of these groups;
• R2 is absent or alkyl(C≤12), cycloalkyl(C≤12), acyl(C≤12), -alkanediyl(C≤6)-Rc, or a substituted version of any of these groups;
• wherein:
• Rc is amino, alkylamino(C≤8), dialkylamino(C≤8), heterocycloalkyl(C≤8), or a substituted version of any of these groups;
• provided that R2 is absent when the atom to which R2 is bound is a part of a double bond, and when the atom to which R2 is bound is part of a double bond, then R2 is absent;
• R3 is absent or alkyl(C≤12), cycloalkyl(C≤12), acyl(C≤12), -alkanediyl(C≤6)-Rc, —(CH2CH2O)mRd, or a substituted version of any of these groups;
• wherein:
• Rc is amino, alkylamino(C≤8), dialkylamino(C≤8), heterocycloalkyl(C≤8), or a substituted version of any of these groups;
• Rd is hydrogen, alkyl(C≤6), or substituted alkyl(C≤6);
• and
• m is 1, 2, 3, 4, or 5;
• provided that R3 is absent when the atom to which R3 is bound is a part of a double bond, and when the atom to which R3 is bound is part of a double bond, then R3 is absent;
• R4 is hydrogen, halo, alkyl(C≤6), or substituted alkyl(C≤6);
• R5 is absent or alkyl(C≤12), acyl(C≤12), or a substituted version of either of these groups;
• provided that R5 is absent when the atom to which R5 is bound is a part of a double bond, and when the atom to which R5 is bound is part of a double bond, then R5 is absent;
• and
• n is 1, 2, 3, or 4;
• provided that when R2 and R5 are acyl(C≤12) or substituted acyl(C≤12), then R3 is alkyl(C≤12) or substituted alkyl(C≤12);
• or a pharmaceutically acceptable salt thereof.