Recombinant HVT vectors expressing multiple antigens of avian pathogens and uses thereof
AssigneeBoehringer Ingelheim Animal Health USA Inc.
InventorsMichel Bublot, Teshome Mebatsion, Joyce Pritchard, Perry Linz, Aemro Kassa
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Abstract
The present invention provides recombinant herpesvirus of turkeys (HVT) vectors that contain and express antigens of avian pathogens, compositions comprising the recombinant HVT vectors and polyvalent vaccines comprising the recombinant HVT vectors. The present invention further provides methods of vaccination against a variety of avian pathogens and method of producing the recombinant HVT vectors.
Claims23
A method of inducing a protective immune response in an animal against an avian pathogen, comprising:
- administering to the animal an effective amount of a vaccine comprising a recombinant herpesvirus of turkeys (HVT) vector comprising a first heterologous polynucleotide coding for and expressing an Infectious Laryngotracheitis Virus (ILTV) glycoprotein D (gD) antigen,
- wherein the ILTV gD antigen has at least 80% sequence identity to SEQ ID NO:17, the first heterologous polynucleotide has at least 70% sequence identity to SEQ ID NO:16, or both.
A method of inducing a protective immune response in an avian against an avian pathogen, comprising:
- administering to the avian an effective amount of a composition comprising a recombinant HVT vector, wherein the recombinant HVT vector comprises:
- a first heterologous polynucleotide coding for and expressing an Infectious Laryngotracheitis Virus (ILTV) glycoprotein D (gD) antigen, wherein the ILTV gD antigen coded by the first heterologous polynucleotide has at least 80% sequence identity to SEQ ID NO:17, the first heterologous polynucleotide has at least 70% sequence identity to SEQ ID NO:16, or both;
- and
- a second heterologous polynucleotide coding for and expressing an Infectious Bursal Disease Virus (IBDV) VP2 antigen, an Infectious Laryngotracheitis Virus (ILTV) glycoprotein D (gD) antigen, or a Newcastle Disease Virus F (NDV-F) antigen.
Dependencies are inferred from the claim text.