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AssigneesThe Broad Institute, Inc., Massachusetts Institute of Technology, President and Fellows of Harvard College, The Brigham and Women's Hospital, Inc.
InventorsAviv Regev, Vijay Kuchroo, Hongkun Park, Nir Yosef, Alexander K. Shalek, Jellert Gaublomme, Nicole C. Joller, Chuan Wu, Ana Carrizosa Anderson
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This invention relates generally to compositions and methods for identifying the regulatory network that modulates, controls or otherwise influences T cell balance, for example, Th17 cell differentiation, maintenance and/or function, as well compositions and methods for exploiting the regulatory network that modulates, controls or otherwise influences T cell balance in a variety of therapeutic and/or diagnostic indications. This invention also relates generally to identifying and exploiting target genes and/or target gene products that modulate, control or otherwise influence T cell balance in a variety of therapeutic and/or diagnostic indications.
A method for increasing a non-pathogenic phenotype and/or decreasing a pathogenic phenotype in a Th17 cell or a population of Th-17 cells comprising:
Dependencies are inferred from the claim text.