Cells expressing chimeric activating receptors and chimeric stimulating receptors and uses thereof

An immune cell comprising:

• a) a chimeric antibody-T cell receptor (TCR) construct (caTCR) comprising:
• i) an antigen binding module that specifically binds to a target antigen;
• and
• ii) a T cell receptor module (TCRM) comprising a first TCR domain (TCRD) comprising a first TCR transmembrane domain (TCR-TM) and a second TCRD comprising a second TCR-TM, wherein the TCRM facilitates recruitment of at least one TCR-associated signaling molecule, wherein the caTCR further comprises a stabilization module comprising a first stabilization domain and a second stabilization domain, and wherein the stabilization module is selected from the group consisting of a CH1-CL module, a CH2-CH2 module, a CH3-CH3 module, and a CH4-CH4 module;
• and
• b) a chimeric signaling receptor (CSR) comprising:
• i) a ligand-binding module that is capable of binding or interacting with a target ligand;
• ii) a transmembrane module;
• and
• iii) a co-stimulatory immune cell signaling module that is capable of providing a co-stimulatory signal to the immune cell,
• wherein the ligand-binding module and the co-stimulatory immune cell signaling module are not derived from the same molecule, and wherein the CSR lacks a functional primary immune cell signaling domain.