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US 10,822,389 B2Granted
Antibody/T-cell receptor chimeric constructs and uses thereof
AssigneeEureka Therapeutics, Inc.
InventorsJingwei Lu, Zhiyuan Yang, Cheng Liu, Hong Liu, Yiyang Xu, Su Yan, Vivien Wai-Fan Chan, Lucas Horan
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Abstract
The present application provides antibody-TCR chimeric constructs comprising an antibody moiety that specifically binds to a target antigen fused to a TCRM capable of recruiting at least one TCR-associated signaling module. Also provided are methods of making and using these constructs.
Claims22
An antibody-T cell receptor (TCR) chimeric molecule (abTCR) that specifically binds to a target antigen, comprising:
- a) a first polypeptide chain comprising a first antigen-binding domain comprising a VH antibody domain and a first T cell receptor domain (TCRD) comprising a first transmembrane domain of a first TCR subunit;
- and
- b) a second polypeptide chain comprising a second antigen-binding domain comprising a VL antibody domain and a second TCRD comprising a second transmembrane domain of a second TCR subunit,
- wherein the VH domain of the first antigen-binding domain and the VL domain of the second antigen-binding domain form an antigen-binding module that specifically binds to the target antigen,
- wherein the first TCRD and the second TCRD form a T cell receptor module (TCRM) that is capable of recruiting at least one TCR-associated signaling module,
- wherein the target antigen is a complex comprising a peptide and an MHC protein, and
- wherein:
- (i) the first TCR subunit is a TCR α chain, and the second TCR subunit is a TCR β chain;
- (ii) the first TCR subunit is a TCR β chain, and the second TCR subunit is a TCR α chain;
- (iii) the first TCR subunit is a TCR γ chain, and the second TCR subunit is a TCR δ chain;
- or
- (iv) the first TCR subunit is a TCR δ chain, and the second TCR subunit is a TCR γ chain.
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Dependencies are inferred from the claim text.