Molecules that bind to SARS-CoV-2
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsDimiter Stanchev Dimitrov, Chuan Chen, Dontcho V. Jelev, John W. Mellors, Wei Li, Zehua Sun
Life of this patent
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Abstract
This document provides methods and materials involved in binding a binder (e.g., an antibody, antigen binding fragment, and/or antibody domain) to a SARS-CoV-2 antigen. For example, binders (e.g., antibodies, antigen binding fragments, and antibody domains) that bind to a SARS-CoV-2 polypeptide and methods and materials for using one or more such binding molecules to treat a mammal (e.g., a human) having COVID-19 (or a viral infection caused by SARS-CoV-2) are provided.
Claims18
An isolated antibody comprising:
- (i) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:1, SEQ ID NO:2, and SEQ ID NO:3, and a light chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:9, SEQ ID NO:10, and SEQ ID NO:11;
- (ii) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:17, SEQ ID NO:18, and SEQ ID NO:19, and a light chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:25, SEQ ID NO:26, and SEQ ID NO:27;
- (iii) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:73, SEQ ID NO:74, and SEQ ID NO:75;
- or
- (iv) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:89, SEQ ID NO:90, and SEQ ID NO:91.
An isolated antigen binding fragment comprising:
- (i) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:1, SEQ ID NO:2, and SEQ ID NO:3, and a light chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:9, SEQ ID NO:10, and SEQ ID NO:11;
- (ii) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:17, SEQ ID NO:18, and SEQ ID NO:19, and a light chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:25, SEQ ID NO:26, and SEQ ID NO:27;
- (iii) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:73, SEQ ID NO:74, and SEQ ID NO:75;
- or
- (iv) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:89, SEQ ID NO:90, and SEQ ID NO:91.
An isolated antibody domain comprising:
- (i) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:73, SEQ ID NO:74, and SEQ ID NO:75;
- or
- (ii) a heavy chain variable domain or region comprising the amino acid sequences set forth in SEQ ID NO:89, SEQ ID NO:90, and SEQ ID NO:91.
Dependencies are inferred from the claim text.