US 10,822,357 B2 · Benzyl compound

Abstract

The purpose of the present invention is to provide a protecting group which improves the solubility of a compound having a functional group protected with the protecting group in an organic solvent and which is easily separated and purified after a reaction with avoiding solidification or insolubilization. Provided is a benzyl compound represented by Formula (1) where X1 represents —CH2OR14 (where R14 represents a hydrogen atom, a halogenocarbonyl group, or an active ester-type protecting group), —CH2NHR15 (where R15 represents a hydrogen atom, a linear or branched alkyl group having 1 to 6 carbon atoms, or an aralkyl group), a halogenomethyl group, a methyl azide group, a formyl group, or an oxime; and at least one of R1, R2, R3, R4, and R5 is a group represented by Formula (2), and the remainders each represent a hydrogen atom, a halogen atom, an alkyl group having 1 to 4 carbon atoms, or an alkoxy group having 1 to 4 carbon atoms, where R6 represents a linear or branched alkylene group having 1 to 16 carbon atoms; X2 represents O or CONR16 (where R16 represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms); and A represents a group represented by Formula (3), (4), (5), (6), (7), (8), (9), (10), (11), (12), or (13).

Claims13

Dependent claims

A benzyl compound of formula (1):

wherein X1 represents —CH2OR14 where R14 represents a hydrogen atom, a halogenocarbonyl group, or an active ester-type protecting group, —CH2NHR15 where R15 represents a hydrogen atom, a linear or branched alkyl group having 1 to 6 carbon atoms, or an aralkyl group, a halogenomethyl group, a methyl azide group, a formyl group, or an oxime;
and
at least one of R1, R2, R3, R4, and R5 is a group of formula (2):
—O—R6—X2-A (2)
and the remainders each represent a hydrogen atom, a halogen atom, an alkyl group having 1 to 4 carbon atoms, or an alkoxy group having 1 to 4 carbon atoms, wherein
R6 represents a linear or branched alkylene group having 1 to 16 carbon atoms;
X2 represents O or CONR16 where R16 represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms;
and
A is a group of formula (3), (4), (5), (6), (7), (8), (9), (10), (11), (12), or (13):
wherein R7, R8, and R9 are the same or different and each represent a linear or branched alkyl group having 1 to 6 carbon atoms or an optionally substituted aryl group;
R10 represents a single bond or a linear or branched alkylene group having 1 to 3 carbon atoms;
and R11, R12, and R13 each represent a linear or branched alkylene group having 1 to 3 carbon atoms,
wherein
when A is a group of formula (3), R7, R8, and R9 are the same.

11 more elements

Dependencies are inferred from the claim text.

Benzyl compound

Life of this patent

Benzyl compound

Life of this patent

Abstract

Claims13